learn from model organisms
transfer experimental knowledge from model organisms to advance our understanding of human biology and disease
Model organisms – such as mouse, zebrafish – have been widely used to uncover molecular mechanisms relevant to human biology, particularly in contexts where human samples are scarce or inaccessible (e.g., the brain). However, evolutionary divergence between species poses significant challenges for direct knowledge transfer, often limiting the translational value of findings. Our lab develops network-based and deep learning approaches to project and contextualize experimental observations from model organisms, with the goal of improving our understanding of human health and disease.