characterize complex human diseases
unravel the genetic basis of complex diseases and disorders using network-based approaches
Complex diseases arise from the interplay of numerous genetic risk variants, environmental influences, and their context-dependent interactions across diverse biological systems. These conditions often present with heterogeneous phenotypes driven by coordinated dysregulation across multiple cell types and tissues. Our lab develops network-based approaches to systematically uncover genetic factors underlying complex disease etiology and to characterize their functional impact in tissue-specific, cell-type-specific, and single-cell contexts.